ultrashort-pulsed laser ablation of poly-L-lactide (PLLA) for cell and tisuee engineering applications

Author: Rocío Ortiz Márquez Thesis director Iban Quintana, Tekniker y Jose Ramón Sarasua, UPV/EHU Date2017

In this thesis, the picosecond pulsed laser ablation technology was considered for manufacturing of surface micropatterns on films and sheets of PLLA (a biocompatible and biodegradable polymer), to investigate the ablation mechanism on this polymer, and the effect of laser-created micropatterns on the response of several cell types via in vitro essays; this investigation was made with the overall goal to elucidate the influence of these topological micropatterns on cell response and asses the laser technology as a method for scaffold manufacturing and surface functionalisation in the tissue engineering field.